The Functions of the Multiproduct and Rapidly Evolving \u3cem\u3edec-1\u3c/em\u3e Eggshell Gene Are Conserved Between Evolutionarily Distant Species of Drosophila

The Drosophila dec-1 gene encodes multiple proteins that are required for female fertility and proper eggshell morphogenesis. Genetic and immunolocalization data suggest that the different DEC-1 proteins are functionally distinct. To identify regions within the proteins with potential biological significance, we cloned and sequenced the D. yakuba and D. virilis dec-1 homologs. Interspecies comparisons of the predicted translation products revealed rapidly evolving sequences punctuated by blocks of conserved amino acids. Despite extensive amino acid variability, the proteins produced by the different dec-1 homologs were functionally interchangeable. The introduction of transgenes containing either the D. yakuba or the D. virilis dec-1 open reading frames into a D. melanogaster DEC-1 protein null mutant was sufficient to restore female fertility and wild-type eggshell morphology. Normal expression and extracellular processing of the DEC-1 proteins was correlated with the phenotypic rescue. The nature of the conserved features highlighted by the evolutionary comparison and the molecular resemblance of some of these features to those found in other extracellular proteins suggests functional correlates for some of the multiple DEC-1 derivatives

Arthropods of Medical Importance in Ohio

Author Institution: Sanitarian, Licking and Knox Counties, Ohi

The Ursinus Weekly, May 13, 1912

Concert at Pottstown • Ursinus trims Swarthmore • Athletic dance • Field cage fund increasing • Chemical-Biological group • Historical-Political group • Dr. Dresser addresses YWCA and YMCA • Miss Hinkle sings • Field day sports • Perkiomen 7, reserves 1 • Norristown pageanthttps://digitalcommons.ursinus.edu/weekly/2770/thumbnail.jp

The Ursinus Weekly, January 13, 1913

Interesting items about alumni • Society notes • Out there at Ursinus • Dr. Omwake gets press notice • Field Cage progress • Mr. Wasser married • English-Historical group • Lecture course number • 1915 class hats • Joint meeting of YM and YWCA • Resolutions of respect • College directory • Football captains for next year • Among other colleges • Math groups meet • Alumni editorshttps://digitalcommons.ursinus.edu/weekly/3099/thumbnail.jp

The Ursinus Weekly, December 16, 1912

Anniversary play judged a success • Activities of Ursinus alumni • Ex-captain Yoh • Seaman elected captain • Freshmen entertained • Glee Club chosen • Christian associations • Classical group meeting • Brotherhood of St. Paul • Ruby calendar • Football squad at Shreinerhttps://digitalcommons.ursinus.edu/weekly/2717/thumbnail.jp

The Ursinus Weekly, November 25, 1912

Directors elect Dr. Omwake president • Letter from Directors • Concert by Handel Choral Society • Action taken by faculty • Fudge social • English-Historical group • Progressive party • Christian associations • Society notes • Football scoreshttps://digitalcommons.ursinus.edu/weekly/2714/thumbnail.jp